The term Biomarker which is also known as biological marker can be defined in a broad
subcategory of medical signs which indicates the medical state observed from
outside the patient which can be reproduced and measured accurately.
Body fluids like blood and other
tissues contains bio-markers which can be a sign of a normal or abnormal
process, or of a condition or disease. Capacity of a patient’s body that
responds to a treatment for a disease or condition can be indicated by
Bio-markers. Such bio-markers are also called as molecular marker and signature
molecule.
They play an important role in the
field of drug discovery and development. Robust drug safety and efficacy
measurements are the challenges for the bio-markers. Their role in drug
development will continue to grow for the foreseeable future. To know the
rightful role of a Bio-marker, greater understanding of the mechanism of
disease progression and therapeutic intervention is needed. Understanding of
the requirements for bio-marker selection and validation, bio-marker assay
method validation and application, and clinical endpoint validation and
application is needed. Bio-markers must be taken into consideration while the
therapeutic target is still being identified and the concept is being
formulated. Development and application of Optimum bio-marker will require a
team approach because of the multifaceted nature of bio-marker selection and
validation. Application of techniques such as pharmacoepidemiology,
pharmacogenetics, pharmacogenomics, functional proteomics, bioanalytical method
development and validation, disease process, therapeutic intervention
assessments, and pharmacokinetic/pharmacodynamic modeling and simulation to
improve and refine drug development are major aspects in clinical bio-markers
in drug discovery and development.
Pharma Medicinal Chemistry 2018 aims
to gather leading educational scientists, researchers and research students to
exchange & share their experiences and research results about all aspects
of Pharmaceutical Science and Medicinal Chemistry. We invite all people who are
interested to explore their research, case studies and practitioners of
Pharmaceutical Chemistry, Drug development and Discovery to the 18th International Conference on Medicinal and
Pharmaceutical Chemistry during October 18-19, 2018 in Dubai, UAE.
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