Pharmaceutical science is often considered as one of the rapidly growing segments of health care. It plays major role in the in the treatment of Cancer through the medicine. Complete removal of the cancer without damage to the rest of the body (that is, achieving cure with near-zero adverse effects) is the ideal goal of treatment and is often the goal in practice.
Current trends in Pharmaceutical Chemistry efforts are moving towards the more targeted approach. Targeted delivery of drugs to tumors represents a significant advancement in Cancer diagnosis and therapy. It uses information about a person’s genes and proteins to prevent, diagnose, and treat disease.
Selection of Breast cancer therapy may be influenced
by the following clinical and pathology features (Simpson, 2000)
·
The age and menopausal status of the patient.
·
The stage of the disease.
·
The histologic and nuclear grade of the primary
tumor.
·
The ER and PR status of the tumor.
·
Human epidermal growth factor type 2 receptor (HER2/neu)
overexpression.
·
Proliferative capacity of the tumor (e.g., Ki67).
The use of hormone replacement
therapy (HRT) poses a dilemma for the rising numbers of breast cancer
survivors, many of whom enter menopause prematurely as a result of therapy. Therefore,
development of Pharmaceutical Nanocarriers or novel tumor-specific ligands is
highly desirable. Monoclonal Antibodies, Gene
expression modulators, Signal transduction inhibitors, Immunotherapies, Angiogenesis
Inhibitors are the novel drug targeted therapies in Cancer treatment.
No comments:
Post a Comment